SHE level 11 SCQF credit points 15 ECTS credit points 7.5 Module code MMC530757 Module Leader Janice Spencer School School of Health and Life Sciences Subject Biological and Biomedical Sciences Trimester A (September start)
Summary of content This module examines, at an in-depth level, the mechanisms employed by bacterial, viral and fungal pathogens of humans to cause disease. Students should gain an understanding of the role of the immune response to prevent infection and the maintenance of homeostasis. There will be an emphasis on priority pathogens, antimicrobial resistance and the requirement for the development of novel treatments and advanced diagnostics.
Module details Syllabus arrow_forward Immunology An overview of the anatomy and physiology of the immune system. This will include an introduction to key anatomical, cellular, and chemical mediators of the immune system and how immune cells orchestrate a response against pathogens. Gut homeostasis, dysbiosis and opportunistic gut pathogens Gut homeostasis and the interaction between host immunity and the intestinal microbiota. Persistent disruption of the gut microbiota (dysbiosis) and the contribution to the decline in human health including inflammatory bowel diseases and infection with Clostridium difficile. C. difficile pathogenesis, diagnosis, and treatment. Crohn’s disease and attaching and invasive Escherichia coli. Fungal infections Clinically significant and emerging fungal pathogens will be covered in detail, specifically focussing on diagnostic and therapeutic considerations. Host-pathogen interactions will also be described, including the immune response recognition to pathogenic fungi, as well as immune evasion mechanisms employed by fungal pathogens to persist and establish infection. Viral Infections Viral outbreaks occur annually on a global basis, with sporadic epidemics leading to high mortality. Most of these outbreaks could potentially be prevented with specific vaccination, education, surveillance, and improvements in outbreak control. Antimicrobial Resistance Antimicrobial resistance (AMR) is a major health issue and an increasingly serious threat to global public health. This study block will introduce the molecular mechanisms behind the development of AMR with an emphasis on the role of mobile genetic elements in the transmission of AMR in both hospital and community settings. The contribution to AMR of agriculture, the environment and global public health policies will be addressed. WHO priority pathogens
Learning outcomes arrow_forward On successful completion of this module, students should be able to: 1. Demonstrate a systematic understanding of the role the immune system has in the maintenance of human health 2. Exhibit a critical awareness of the impact of infectious disease worldwide and summarise the advanced mechanisms used by pathogens of global relevance to cause infection. 3. Criticise and consolidate scientific literature relating to the pathogen, tissue pathology, epidemiology, treatment, and prevention of these infectious diseases. 4. Demonstrate a critical recognition of the requirement for the development of novel treatments of infectious disease
Teaching / learning strategy arrow_forward Students will be taught using recorded lectures and online support mechanisms including quizzes and tutorials, student centred learning and data analysis and interpretation. Student-centred learning will involve chelating information from library resources including current peer reviewed material. Data interpretation sessions will provide exercises in handling scientific data to encourage the consolidation of their taught material and understanding.
Transferrable skills arrow_forward In addition to knowledge of the core lecture material, each student should develop a series of generic skills. These include written and graphical abstract presentation skills time management, scientific writing skills and the theory of innovative laboratory practice. Data analysis skills, problem solving and interpretation of clinical data.
Module structure Activity Total hours Lectures 18 Tutorials 12 Practicals 0 Seminars 0 Independent Learning 110 Assessment 10 Placement 0
Assessment methods Component Duration Weighting Threshold Description Course Work001 100 45 CW01: Data Interpretation