2021-new blueprint for hepC treatment

Scientists reveal blueprint for getting hepatitis C treatment to people who inject drugs

Wed, 11 Aug 2021 10:00:00 BST
Lead researchers in the study Professor Sharon Hutchinson, Professor Lawrie Elliott and Dr Gabriele Vojt
Lead researchers in the study Professor Sharon Hutchinson, Professor Lawrie Elliott and Dr Gabriele Vojt

Scientists have revealed a new method of delivering hepatitis C testing and treatment to people who inject drugs which will help bring the world a step closer to eliminating the virus.

A team of experts, led by Glasgow Caledonian University (GCU) and the University of Bristol, in collaboration with NHS Tayside and the Scottish Drugs Forum (SDF), have just published a ‘game-changing’ blueprint on how best to get hepatitis C treatment to those who need it most after a successful three-year trial in NHS Tayside.

The breakthrough in getting treatment to those who inject drugs – studied as part of the National Institute for Health Research (NIHR)-funded EPIToPe (Evaluating the population impact of hepatitis C direct-acting antiviral treatment as prevention for PWID (people who inject drugs) project – will help guide efforts in Scotland to eliminate hepatitis C by 2024.

Key recommendations include introducing a nurse-led community service for hepatitis C testing and treatment, recruiting peer workers who know the local drug culture and creating close ties between existing community services for people who inject drugs.

Researchers say the ideal model would be to house all these services in one building but where this is not possible the links between these services need to be strengthened including data sharing systems, role sharing and post-treatment care and support. A key part of that support is ongoing testing and treatment to prevent re-infection. It is hoped the guide will be rolled out across the UK and around the world.

The Scottish Government welcomed the findings and Public Health Minister Maree Todd said: “These recommendations will be a valuable resource as we continue to work towards our target of eliminating Hepatitis C in Scotland by 2024.”

The hepatitis C virus (HCV) is a blood-borne disease that can seriously damage the liver and is spread mainly through blood-to-blood contact with an infected person. Despite effective Opioid Substitution Treatment and Needle Syringe Programmes, chronic hepatitis C prevalence remains at around 40% among people who inject drugs in the UK.

The World Health Organization (WHO) has set an elimination target to reduce hepatitis C transmission by 80% and deaths by 65% by 2030, and researchers believe this new method of getting treatment to those who inject drugs in communities will have a major impact on cutting incidence and death rates.

Lead GCU researchers behind the blueprint, Professor Lawrie Elliott, Dr Gabriele Vojt and Professor Paul Flowers, now at Strathclyde University, described the research as a “game changer in the design of hepatitis C treatment programmes for those who inject drugs in Scotland and beyond”.

Professor Elliott added: “We know from previous research led by GCU that the treatment works but we have struggled to get this out to those who need it. These recommendations are a major breakthrough in getting treatment out to communities and will have a huge impact on virus elimination.”

EPIToPe study co-lead and GCU Professor of Epidemiology and Population Health Sharon Hutchinson, said: “The lessons learnt from the great strides made in NHS Tayside in tackling hepatitis C are captured in the set of recommendations. They have shown that it is feasible to deliver specialist nurse-led treatment across multiple community-based services engaged with people who inject drugs.

“The set of EPIToPe recommendations will help to guide other regions and countries in efforts to rapidly scale up hepatitis C treatment in this population, as is necessary to achieve the global WHO elimination targets.”

The study was co-led by Matt Hickman, Professor in Public Health and Epidemiology and co-Director of the NIHR Health Protection Research Unit in Behavioural Science and Evaluation at University of Bristol, and involved experts from the University of Dundee, Public Health Scotland, and NHS Bristol, North Somerset and South Gloucestershire, with the backing of drugs charities With You and The Hepatitis C Trust.

NHS Tayside Consultant Hepatologist and Gastroenterologist and University of Dundee Professor John Dillon said: “The goal of HCV elimination, removing the scourge of death and disease caused by HCV from our communities is within reach, but it needs coordinated action by all the players to achieve it. The recommendations are a useful tool to that end.”

Professor Hickman said scaling up hepatitis C testing and treatment in the community alongside harm reduction services was “critical” to prevention in the UK and achieving elimination targets.

“This is a very useful blueprint with practical suggestions for services and commissioners on how scale-up can be done – based on the successful transformation of services in NHS Tayside,” he added.

SDF CEO David Liddell welcomed the blueprint: “This type of assertive, responsive and inclusive approach to hepatitis C testing and treatment will go a long way to helping Scotland meet its 2024 elimination target.

“The recommendations have given us an evidence base for actions around which a consensus can readily be built as they will be consistent with the experiences of stakeholders delivering services.”

Dr Paul Hughes, Executive Medical Director at With You, said: “With You welcomes the publication of the EPITOPe study. The study findings will undoubtedly contribute to our organisational aim of helping NHS England's to eliminate Hepatitis C by 2025.”

CASE STUDY

Scott MacBlackScott MacBlack, a 42-year-old dad who got hepatitis C after injecting drugs, praised the recommendations and said “stuff like this should be happening”.

Scott, from Irvine, Ayrshire, explained: “I started taking drugs from a very early age, smoking cannabis and talking pills which then developed into the harder drugs like heroin.

“I wasn’t educated on this kind of stuff and before long I started injecting. It went on for years and I ended up in and out of prison. In my second or third time in prison I was tested for hepatitis C and it came back positive.

“I was given interferon to begin with but the side effects made me really unwell. It was horrible and it didn’t cure me. No-one really knew what to do about it so I lived with hep C for another 20 years.

“I felt stigmatised. Firstly, for using drugs and then also because of my hep C. I couldn’t be truthful about it because people didn’t know much about it back then. I got sent back to prison again and through word of mouth I heard about this new treatment Direct Acting Antivirals (DAAs), I didn’t know much about it and was sceptical.

“Finally, I chatted to one of the nurses and decided to go through with it. It was the best decision I’ve ever made. I didn’t have any side effects, took one tablet a day for 12 weeks and was cured. It was only after getting rid of it that I realised how big a weight had been lifted off my shoulders with this, both physically and mentally. The weight of feeling stigmatised for my hep C had been lifted.”

Commenting on the recommendations, Scott said: “Stuff like this should be happing. It’s getting to the people with hep C and dealing with it directly. It takes away the barriers for people who are using drugs and actually treating them in a way that’s accessible. With regards to peer workers, I don’t think there’s anyone better who could be doing this. They can relate and that gives that extra level of support so working hand in hand with professionals, there’s no better way to do this.”