Chemotherapy resistance

Scientists from Glasgow imported a cutting-edge research technique from the US in a bid to increase survival rates in patients diagnosed with an aggressive form of cancer. A 3D model system which recreates how leukaemic cells interact with bone marrow could help make chemotherapy more effective for adults with acute myeloid leukaemia (AML).

AML develops rapidly and chemo is used to kill as many leukaemia cells as possible. However, some cells can cluster together and become resistant to treatment.

Dr Mark Williams, lecturer in cell and molecular biology at GCU, is leading an academic-industry partnership that was awarded a £10,000 grant by the British Society for Haematology to bring the new form of testing to the UK.

Understanding how these cells behave is crucial, not only to drive the development of new drugs but also to repurpose existing ones to enhance survival rates.

Dr Mark Williams
School of Health and Life Sciences