SHE Level 5
SCQF Credit Points 15.00
ECTS Credit Points 7.50
Module Code MMC723487
Module Leader n/a
School School of Health and Life Sciences
Subject Biological and Biomedical Sciences
  • A (September start)

Pre-Requisite Knowledge

BSc Hons Biomedical Science at 2.2 or equivalent as specified in Programme Admissions Criteria

Summary of Content

This module will develop an understanding of the molecular genetic basis of inherited and somatic disease in humans with a particular focus on cancer, diabetes and atherosclerosis.


The biology of cancer cells Oncogenes, src, abl, ras Tumor suppressor genes, Rb, NF1, WT1, APC, Smad4, p53 Cell cycle and cancer p53, Rb, p16, p21, p27, ATM/ATR, CHK1/CHK2, ARF Identification of cancer genes in the post genome era, CGP, TCGA, B-raf Role of lipoproteins in atherosclerosis Monogenic disorders of LDL metabolism: LDLR , APOB and ARH Monogenic disorders of LDL metabolism: PCSK9 Monogenic disorders of HDL metabolism Introduction to Diabetes Mendelian genetics & molecular analysis Mendelian genetics and complications of interpreting pedigree patterns Organization of the human genome. Mutation detection. Molecular pathology Monogenic diabetic disorders Type 2 diabetes: candidate genes Type 2 diabetes: genome wide scanning Aetiology of type 2 diabetes: a polygenic disorder Aspects of the treatment of diabetes mellitus Aspects of the human genome Epigenetics; Covalent modification of DNA and histones and gene activation and silencing Inactivation of the X-chromosome. Gene imprints and disease Transgenerational inheritance of epigenetic states. Human genetic variation: SNPs and CNVs Functional views of the genome revealed by the ENCODE project.

Learning Outcomes

On successful completion of this module the student should be able to:1) Demonstrate an advanced understanding of experimental approaches to disease gene discovery and function.2) Recognise bioinformatics informs progress in molecular genetics.3) Discuss the diagnosis, biology, molecular pathology and treatment of inherited and somatic diseases.4) Evaluate current literature related to diseases discussed in lectures5) Demonstrate the synthesis of knowledge and information derived from multiple sources

Teaching / Learning Strategy

The module initially utilizes a convergent teaching approach with each topic in order to ensure that the different student groups taking the module quickly achieves the required background. Thereafter, each lecture topic is discussed using evidence based teaching which facilitates divergent thinking . Evidence based learning of new scientific findings develops the students ability to critically analyse new ideas and how these extend current concepts. The subject areas covered in the module are at the leading edge of science providing the student with an advanced understanding. Student centred learning involves continuous assessment promoting both engaged learning and broader deeper learning of often complex subject material. The students consider diseases which have major worldwide health implications which combined with knowledge of the latest technologies for disease investigation, diagnosis and treatment provides global learning opportunities of significant real world problems .

Indicative Reading

Molecular Biology of the Cell, 6 th edition (2015), Garland Science The Biology of Cancer , Robert A. Weinberg, 2 nd edition (2014), Garland Science Genetics and Genomics in Medicine, Tom Strachan (2015), Garland Science

Transferrable Skills

Information retrieval Independent learning Critical evaluation Interpretation and analysis of data Written and oral communication

Module Structure

Activity Total Hours
Lectures (FT) 30.00
Assessment (FT) 20.00
Independent Learning (FT) 100.00

Assessment Methods

Component Duration Weighting Threshold Description
Coursework 1 n/a 25.00 45% Student Centred Learning.
Exam (Exams Office) 2.00 75.00 45% Unseen written exam. 3 essay questions from a total of 6 questions).