METABOLIC AND VASCULAR DISEASES

SHE Level 5
SCQF Credit Points 15.00
ECTS Credit Points 7.50
Module Code MMB126407
Module Leader Steven Patterson
School School of Health and Life Sciences
Subject Biological and Biomedical Sciences
Trimester
  • A (September start)

Pre-Requisite Knowledge

At least a 2:2 honours degree (or equivalent) in a biomedical or biological science discipline.

Summary of Content

This module will develop current understanding and critical evaluation of metabolic and endocrine health and the pathophysiological factors (genetic and acquired) leading to an array of metabolic diseases and their associated co-morbidities, including vascular diseases. This will include the role of circadian biology in health, obesity and associated diseases including non-alcoholic fatty liver disease and diabetes mellitus, and an array of vascular diseases. Genetic inborn errors of metabolism and lipid metabolism, as well as current and developing screening approaches will be explored.

Syllabus

Circadian biology in health and disease: role of central and peripheral clock genes in regulating normal circadian rhythms essential for health. Disruptors of circadian rhythm (shift work, travel, poor sleep patterns, sleep apnoea). Developments in potential role of circadian biology on screening and management of diseases will be explored. Obesity: obesity as a disease, genetics factors in obesity, relevance of the gut microbiome to obesity, hyperinsulinaemia and insulin resistance, non-alcoholic fatty liver disease -pathogenesis, screening, complications and treatment. Potential use of metabolomics and microRNA profiling in prediction of risk of vascular disease and Type 2 diabetes. Diabetes Mellitus - pathogenesis, genetics, pathology, screening, testing, monitoring and management - current and developing perspectives. This will include Type 1 diabetes, Type 2 diabetes, monogenic diabetes, gestational diabetes. Pathological findings in Type 1 and Type 2 diabetes related to disease pathogenesis. Complications in diabetes (acute and chronic). Treatments and developments in diabetes management. Inborn errors of metabolism - genetics, biochemical changes, newborn screening and diagnosis and therapeutic strategies for these conditions. Vascular diseases - lipid transport, lipoproteins and genetic disorders of lipid metabolism and transports, pathological mechanisms underlying atherosclerosis, ischaemic heart disease, myocardial infarction, heart failure, stroke and damage to microvasculature. Diagnosis and monitoring, classification and clinical management of these vascular conditions. Histopathology of the heart and vascular system in disease

Learning Outcomes

On successful completion of the module the student should be able to:1. Demonstrate understanding of the role of circadian rhythm in health, and the factors and roles of disturbances in contributing to metabolic diseases. 2. Integrate knowledge and understanding of concepts relating to acquired and genetic metabolic and endocrine diseases including obesity and diabetes and critically evaluate the current literature around pathogenesis, diagnosis, screening and management of these diseases.3. Understand the relevance of lipid metabolism, lipid transport and lipid trafficking defects in vascular disease pathogenesis.4. Apply knowledge of link between metabolic disarray and vascular complications and defects to evaluate relevance of screening, monitoring and therapeutic management of vascular diseases.

Teaching / Learning Strategy

The main strategies for module delivery will include lectures, a range of student-centred learning exercises, and the use of online digital learning platforms and databases. The teaching strategy will progressively develop the use of peer-reviewed journal articles and internet databases. Students will be directed towards appropriate research and content specific reading resources.

Indicative Reading

Medical Sciences, 2 nd Ed. Naish J & Syndercombe Court D (2015) Sauders Elsevier, Philadelphia ISBN-9780702051388 Clinical Chemistry and Molecular Diagnostic, 7 th ed Burtis CA and Bruns DE (2015) Elsevier, Philadelphia ISBN-9781455741656 Inherited Metabolic Disease: A clinical approach 2 nd Ed. Hoffmann GF, Zschocke J & Nyhan WL (2017) Springer-Verlag Berlin Heidelberg. ISBN 978-3-662-49410-3 (eBook) A large proportion of information will be from current research and students will be directed towards appropriate literature/review articles and current research pap ers on each topic by the staff delivering the teaching.

Transferrable Skills

Students will build on and develop information retrieval skills, and enhance their ability to review, critically analyse, interpret and reflect on the strengths and limitations of current published literature in the areas of metabolic and vascular diseases. Students will develop problem solving and communication skills in preparation of case studies and data interpretation.

Module Structure

Activity Total Hours
Assessment (FT) 30.00
Independent Learning (FT) 90.00
Lectures (FT) 30.00

Assessment Methods

Component Duration Weighting Threshold Description
Course Work 01 2.00 40.00 45% Data Interpretation
Exam 01 2.00 60.00 45% Unseen Written Exam