BLOOD SCIENCES

SHE Level 2
SCQF Credit Points 40.00
ECTS Credit Points 20.00
Module Code M2C926376
Module Leader Deborah O'Donnell
School School of Health and Life Sciences
Subject Biological and Biomedical Sciences
Trimester
  • B (January start)

Pre-Requisite Knowledge

M1B126370 Human Physiology Co-Requisite Knowledge M2C723491 Mechanisms of Cellular Regulation

Summary of Content

The module will allow students to develop an understanding of basic immunology, clinical biochemical and haematological disorders and transfusion science. Students will also develop an in-depth knowledge of the laboratory investigations performed in the diagnosis and management of these disorders. Laboratory Quality Assurance and Control will be covered including Point of Care testing.

Syllabus

Clinical Biochemistry Investigation of the function and dysfunction of body systems, organs and tissues by measurement of biochemical markers. The range and methods used for collection of clinical samples will be explored alongside the principles and application of investigations, including automation, used for screening, differential diagnosis, treatment and monitoring of disease. Pathophysiological conditions will include, disorders of renal, endocrine & hepatic systems, carbohydrate & mineral metabolism, acid-base balance and plasma proteins & enzymes as disease markers. Haematology Investigation of the constituents of blood in normal and disease states. Regulation of haemostasis, diagnosis of anaemias, haematological malignancies, haemorrhagic and thrombotic diseases will be explored including techniques employed in their investigation. Transfusion Science Identification of blood group antigens and antibodies, including the genetics, inheritance, structure and role of red cell antigens. Mechanism and consequences of immune-mediated red cell destruction. Preparation, storage and use of blood components and the selection of these for transfusion and risks of adverse events. Immunology Structure, function and mechanisms of action of the components of the immune system. Investigation of innate and acquired immunity and acute and chronic inflammation.

Learning Outcomes

On successful completion of the module the student should be able to:1. Demonstrate a basic knowledge of immunology & the immune system.2. Demonstrate an understanding of the biochemical & haematological basis of routinely performed laboratory tests to aid diagnosis and management of disease.3. Interpret and critically evaluate laboratory results used in the diagnosis & monitoring of pathophysiological states.4. Demonstrate knowledge of haematopoiesis & structure & function of blood cells.5. Show an understanding of haemostasis & consequences of deficiencies.6. Describe blood group systems & their clinical significance.7. Demonstrate understanding of preparation, storage & use of blood components and there appropriate selection for transfusion and haematological disorders & possible adverse effects.8. Show knowledge of laboratory QA/QC procedures including automation and Point of Care.

Teaching / Learning Strategy

Lecture and tutorials, including use of case-studies and student-centred learning. Lectures used to present core material whilst tutorials will encourage students to evaluate and consolidate their knowledge base. Students will be supported by the use of the managed virtual learning environment (GCULearn).

Indicative Reading

Biomedical Science Practice, Ahmed, Glencross & Wang (2 nd Edition) Oxford University Press (2016) An Introduction to Biomedical Science in Professional and Clinical Practice, Pitt and Cunningham, Wiley (2013) Clinical Biochemistry, Ahmed, (2 nd Edition), Oxford University Press, (2016) Lecture Notes on Clinical Biochemistry, Rae, Crane & Pattenden (10 th edition) Wiley-Blackwell (2017) Clinical Biochemistry: An Illustrated Text, Murphy, Srivastava and Deans (6 th edition), Elsevier (2018) Essential Haematology, Hoffbrand and Steensma (8 th edition) Wiley-Blackwell (2019) Haematology: An Illustrated Colour Text, Howard and Hamilton, (4 th edition) Churchill Livingston (2013) Haematology, Moore, Knight & Blann (2 nd Edition), Oxford University Press (2016) Modern Blood Banking and Transfusion Practices, Harmening (7 th edition) Blackwell (2018) Transfusion & Transplantation Science, Avent (2 nd Edition), Oxford University Press, (2018) Clinical Immunology, Hall, Scott & Buckland, (2 nd edition), Oxford University Press (2016) The Immune System, Parham, (4 th edition), Blackwell (2014)

Transferrable Skills

Data Analysis and interpretation Written communication skills Independent study skills Ability to retrieve and collate information using textbooks, library and on-line resources.

Module Structure

Activity Total Hours
Lectures (FT) 48.00
Independent Learning (FDL) 30.00
Independent Learning (FT) 307.00
Tutorials (FT) 12.00
Assessment (FT) 3.00

Assessment Methods

Component Duration Weighting Threshold Description
Course Work 01 n/a 50.00 35% Data Analysis/Case Study
Exam 02 2.00 25.00 35% Unseen written exam
Exam 01 1.00 25.00 35% unseen written exam