IMMUNOLOGY

SHE Level 2
SCQF Credit Points 10.00
ECTS Credit Points 5.00
Module Code M2C523889
Module Leader Gillian Gibson
School School of Health and Life Sciences
Subject Biological and Biomedical Sciences
Trimester
  • B (January start)

Pre-Requisite Knowledge

New CAB1

Summary of Content

The lecture series aims to cover the topic of Immunology. Basic concepts will be taught and expanded on throughout the course. In addition, the relationship between the immune system in health and disease will be explored. Students will be required to sit a terminal exam (70%) and submit coursework in the form of a Student Centred Learning exercise (30%). The tutorial programme will supplement the lecture material. The tutorial programme will supplement the lecture material. Students will engage in blended learning to enhance engagement with lecture material.

Syllabus

Overview of the Immune System Haematopoiesis and immune cell lineage (lymphocytes, granulocytes, NK cells, dendritic cells). Lymphoid tissues (bone marrow, thymus, lymph nodes, spleen, GALT). Circulation of immune cells in lymphoid tissues. Introduce the different immune responses, adaptive, innate and humoral (to be expanded on later in the lecture series). Cytokines & Chemokines Overview of the major players, IL-2,4,6, IF N-e3, TNF-e1, TGF-e2. Providing sufficient detail and allowing for expansion later in the lecture series. Innate Immunity Main topics covered; neutralisation, opsonisation and phagocytosis of bacterial pathogens. Classical and alternative complement pathway. Phagolysosome formation and release of anti-microbial peptides & acute phase proteins. Cells involved; macrophages, neutrophils, NK cells. Adaptive Immunity Antigen processing and presentation via professional antigen presenting cells; macrophages and dendritic cells and MHC molecules. T-cell activation and differentiation (CD4[Th1 & Th2, Th17, TREG], CD8). Co-stimulation, T-cell receptor, IL-2 and clonal expansion. Principle of naive T-cells and T-cell priming. B-cell Activation (Co-stimulation, Plasma cells [antibody production] and Memory Cells). Effector mechanisms of T & B cells. Antibodies Structure, Polyclonal & Monoclonal, Generation of Diversity, Ab-Ag reaction (immunogenicity). Revise the role of antibodies in innate immunity, neutralisation, opsonisation and interaction with Fc receptor on APC's and complement involvement. Immune Tolerance Positive and Negative selection, clonal deletion, clonal ignorance. Central and peripheral tolerance. T-cells, B-cells and NK cells. Failure of tolerance in autoimmune disease using examples: - Myaesthenia Gravis, Rheumatoid Arthritis, Type 1 Diabetes, Hashimoto's Thyroiditis, Goodpastures syndrome, Graves disease, Coeliacs disease. Immune Evasion Viral and bacterial evasion. Examples; Herpes, Varicella Zoster, EBV, Influenza, Listeria, TB. Various mechanisms employed by pathogens to evade the immune response. Short focus on HIV, epidemiology and pathogenesis. Introduce immunosurveillance and immunotherapy in cancer. Allergic reaction Hypersensitivity reactions discussed using clinical examples such as asthma and food allergies. Transplantation HLA matching, host rejection, Graft vs Host disease

Learning Outcomes

On successful completion of this module the student should be able to:1) Demonstrate a broad knowledge of Immunology2) Define specific concepts in immunology, as outlined in the Syllabus3) Relate their knowledge of immunology to the degree programme under study. 4) Integrate their understanding of the immune system with practical skills in laboratory modules

Teaching / Learning Strategy

Lectures and tutorials, student centred learning and provision of online study aids.

Indicative Reading

Recommended Texts:- b7 Parham. "The Immune System" 4th Ed. Garland Science, NY & London 2015 b7 Janeway, Murphy, Travers & Walport. "Immunobiology" 8th ed. Garland Science, NY & London 2012 -359b7 ChaChapel, Haeney, Misbah & Snowden. "Essentials of Clinical Immunology" 6th Ed. Wiley Blackwell, 2014 b7 X Wood. "Understanding Immunology" 2nd Ed. Pearson 2006 b7 Hall & Yates. "Immunology". Fundamentals of Bioscience (IBMS). Oxford 2010

Transferrable Skills

Work independently & with others in a self-directed and tutor led manner; develop study and IT skills; prioritise workload and work to deadline; improve communication skills.

Module Structure

Activity Total Hours
Lectures (FT) 22.00
Independent Learning (FT) 64.00
Assessment (FT) 10.00
Tutorials (FT) 4.00

Assessment Methods

Component Duration Weighting Threshold Description
Coursework 1 n/a 30.00 35% SCL
Exam (Exams Office) 1.50 70.00 35% Exam - Exams Office MCq & Short Answers