SHE Level 4
SCQF Credit Points 30.00
ECTS Credit Points 15.00
Module Code MHB123735
Module Leader Elaine Gribben
School School of Health and Life Sciences
Subject Biological and Biomedical Sciences
  • A (September start)-B (January start)

Pre-Requisite Knowledge

Successful completion of Respiratory Physiology 1 and 2

Summary of Content

The module will extend the student's knowledge of gas exchange, blood gas transport, exercise physiology, and lung mechanics. It will investigate advanced techniques to investigate patient's response to exercise, to assess the mechanical properties of the lungs and gas exchange. The module will investigate the invasive and non-invasive methods available for the measurement and assessment of blood gas status.


Exercise Physiology: Ventilatory cardiac and circulatory response to exercise. Limitations to exercise, Anaerobic threshold, Recovery from exercise, Reference values, Effects of ageing, obesity and underweight on exercise performance, Exercise induced asthma. -567 Use of pulse oximetry in exercise and sleep, limitations and probe types. Respiratory muscle physiology: Inspiratory and expiratory muscles, pressure changes airway resistance Gas exchange and acid base balance: Gas exchange, oxygen and carbon dioxide transport, effects of shunts, acid base control, Normal values and terminology, Acid base balance, type 1 and type 2, blood gases Respiratory mechanics: airway resistance, compliance, dynamic properties of lungs, work of breathing, measurements. Field exercise tests to include: Cardiac and respiratory responses, other disorders, contraindications and test ends. Indications for tests -567 Field exercise tests: 6 and 12 minute walk tests, Incremental walk tests, oxygen assessment in exercise, objective measurements and symptom measurement. Indications and contraindications for testing. Practical experience of tests, measurements and reporting results. Cardio-pulmonary exercise testing - concepts and indications for testing. Exercise induced Asthma: Indications and contraindications, performance guidelines, measurements obtained, practical experience and observation of tests and reports. Respiratory Muscle Function: Mouth pressures, sniff pressures, vital capacity, normal values and interpretation of results, common diseases. Invasive and Non-Invasive blood gas measurement: Safety procedures, analysers, sampling procedures, normal values, transcutaneous PO 2 and PCO 2 , end-tidal CO 2 measurements, measurements in sleep, exercise, LTOT, Flight assessment, ambulatory oxygen assessment. For special topics, students can choose to study 2 from the following list: Unit 1: Psychopharmacology Unit 2: Neuropathophysiology and therapeutics Unit 3: System Pathophysiology and Pharmacology 1 - Cardiovascular system Unit 4: System Pathophysiology and Pharmacology 2 - Respiratory and GI systems -502 Unit 5: System Pathophysiology and Pharmacology 3 - Pulmonary system

Learning Outcomes

On successful completion of this module the student should be able to:1. critically appraise the physiological processes that contribute to the physiological response to exercise in normal subjects and patients2. explain the mechanics of breathing and the dynamic properties of the lungs3. discuss how these may be altered in disease states4. evaluate the contribution of advanced respiratory function tests in the assessment of patients5. discuss the physiological processes that contribute to the maintenance of normal blood gases

Teaching / Learning Strategy

Although delivered in year 3 this module is set and assessed at level 4 as the syllabus is continuous with Respiratory Physiology 4 with special topics; students are working towards final qualification as a Clinical Physiology Practitioners The specialist module material will be delivered mainly by senior NHS Practitioners, clinicians and consultants via a combination of lectures and tutorials together with directed learning exercises, practical problems and data interpretation. Lectures will provide the foundation material for the module which will be supplemented and enhanced by material presented in tutorials and practical sessions. Tutorials will also allow practical applications of individual topics to the students' own work experience to be examined and discussed. Special topics will be delivered by research active GCU staff

Indicative Reading

Suggested Reading: Cloutier, M. (2007), Respiratory Physiology , Mosby Dakin, J. et al (2003), Making Sense of Lung Function Tests , Arnold Davis, A., Moore, C. (2010), The Respiratory System , 2 nd Edition, Churchill Livingstone Martini, F.H. et al . (2014) Fundamentals of Anatomy & Physiology . 10 th Edition. Pearson. Naish, J. et al . (2011) Medical Sciences . Saunders. Porth, C. M. 9th Edition (2013) Pathophysiology: Concepts of Altered Health States. Lippincott, Williams and Wilkins Rang, H.P. et al . (2015) Rang & Dale's Pharmacology . 8 th Edition. Churchill Livingstone. Tortora, G.J., Derrickson, B.H. (2014), Principles of Anatomy & Physiology. 14th Edition. John Wiley and Sons.

Transferrable Skills

Data analysis and interpretation Problem solving Practical skills Application of theory to practice Time management Team-working during group sessions Communication skills Critical analysis Self-directed study

Module Structure

Activity Total Hours
Practicals (FT) 5.00
Lectures (FT) 80.00
Assessment (FT) 30.00
Independent Learning (FT) 155.00
Tutorials (FT) 30.00

Assessment Methods

Component Duration Weighting Threshold Description
Exam (Dept) 01 3.00 70.00 35% Unseen, to assess discipline specific material
Exam (Dept) 02 1.50 30.00 35% Unseen, to assess special topics content