Publications

For the latest publications and reports, please see details below:

 

EPIToPe (Evaluating the Population Impact of Hepatitis C Direct Acting Antiviral Treatment as Prevention for People Who Inject Drugs)

An estimated 200,000 people in the UK have been infected with the Hepatitis C Virus (HCV), which is an important cause of liver disease, cancer and death.  Most HCV infections in the UK are in people who inject drugs. New Direct Acting Antiviral (DAA) HCV therapies now combine high cure rates (>90%) with short treatment duration (8-12 weeks). 

EPIToPe (Evaluating the Population Impact of Hepatitis C Direct Acting Antiviral Treatment as Prevention for People Who Inject Drugs) aims to generate empirical evidence on the effectiveness of HCV “Treatment as Prevention“in People who Inject Drugs (PWID). Despite effective prevention interventions, chronic HCV prevalence is still 40% among PWID. Evidence from mathematical modelling suggests that HCV treatment is essential to achieving substantial reductions in HCV prevalence and incidence among PWID.  EPIToPE aims to test whether scaling up HCV DAA treatment will reduce chronic HCV prevalence and transmission among PWID.

As part of EPIToPe, a set of evidence-based, theory-informed and stakeholder-driven recommendations has been produced, with information on how best to upscale and optimise the delivery of Hepatitis C testing and treatment in various community settings. To find out more, download EPIToPe Recommendations.‌

 

LUSTRUM (Limiting Undetected Sexually Transmitted Infections to Reduce Morbidity)

Around half a million STIs are diagnosed in the UK each year causing significant morbidity and rising health care costs. Sexual health services are under considerable pressure and are failing to meet demand.  Almost 20% of all HIV infections are undiagnosed despite widely available testing. More effective prevention of transmission and detection of undiagnosed HIV would confer considerable health gains.

LUSTRUM aims to improve the sexual health of heterosexual people and men who have sex with men by preventing transmission of STIs and reducing undiagnosed HIV. This five year mixed methods programme unites multidisciplinary experts from eight academic and NHS institutions. The central component is a definitive cluster RCT of APT, a new form of rapid testing and treatment of sex partners of people with chlamydia, UK’s most commonly reported STI.

Hear more about the latest findings from LUSTRUM by viewing the video.

 

ECONI (Evaluation of Cost of Nosocomial Infection)

A world-leading study led by Glasgow Caledonian University (GCU) has revealed for the first time the full impact of hospital associated infections (HAIs) on patients and cost to NHS Scotland. Researchers found that 7,500 hospital patients or one in every hundred develop HAIs, also known as Nosocomial Infection (NI), each year – costing NHS Scotland £46.4 million annually. The findings from the ECONI project were published in a special issue of the Journal of Hospital Infection. Professor Jacqui Reilly, ECONI Chief Investigator and GCU’s Safeguarding Health through Infection Prevention (SHIP) research group lead, said: “This study gives Scotland the first comprehensive assessment of the incidence, risks and costs of all types of HAI, enabling annual planning of infection prevention and control (IPC) strategy in our hospitals locally and nationally". The Scottish Government, who commissioned the study, welcomed the findings and Scotland’s Associate Chief Nursing Officer Irene Barkby said the results will help the NHS prevent infections and improve patient treatment.

Read the series of 5 papers from the ECONI project in the special issue of the Journal of Hospital Infection.

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Research exposes gaps in mental health support for frontline nurses

Researchers have found gaps in mental health support for frontline respiratory nurses and their families during the COVID-19 pandemic. GCU health services researcher Dr Nicola Roberts is the Principal Investigator in a new research paper entitled ‘Experiences of nurses caring for respiratory patients during the first wave of the COVID-19 pandemic: an online survey study’. Dr Roberts worked with colleagues at Edge Hill University and Southampton University exploring the experiences of nurses caring for respiratory patients during the first wave of the pandemic in early 2020. The paper was published in the BMJ Open Respiratory Journal. The research team analysed responses from over 255 nurses throughout the UK who highlighted concerns over their working environment, the supply and availability of adequate PPE, the quality-of-care individuals were able to deliver, and impacts on mental health to nurses and their families.

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To view the latest publications and reports by research group, please click on the links below.

Ageing Well

Physical Function and Health-Related Quality of Life in Older Adults with or at Risk of a Mobility Disability Post-discharges: 8-month follow-up of a randomized controlled trial, Journal of Aging and Physical Activity

Urban blue spaces and human health: A systematic review and meta-analysis of quantitative studies, Cities

Experiences of nurses caring for respiratory patients during the first wave of the COVID-19 pandemic: an online survey study, BMJ Open Respiratory Journal

Joint association between accelerometry-measured daily combination of time spent in physical activity, sedentary behaviour and sleep and all-cause mortality: a pooled analysis of six prospective cohorts using compositional analysis, British Journal of Sports Medicine

Interventions for reducing sedentary behaviour in community‚Äźdwelling older adults, Cochrane Review

Effects of Regular Physical Activity on the Immune System, Vaccination and Risk of Community-Acquired Infectious Disease in the General Population: Systematic Review and Meta-Analysis, Sports Medicine

Levels of resilience, anxiety and depression in nurses working in respiratory clinical areas during the COVID pandemic, Journal of Respiratory Medicine

The Impact of Regeneration and Climate Adaptations of Urban Green–Blue Assets on All-Cause Mortality: A 17-Year Longitudinal Study, International Journal of Environmental Research and Public Health

Mechanisms of Impact of Blue Spaces on Human Health: A Systematic Literature Review and Meta-Analysis, International Journal of Environmental Research and Public Health

Effectiveness of pelvic floor muscle training with and without electromyographic biofeedback for urinary incontinence in women: multicentre randomised controlled trial, British Medical Journal

Systematic Review of Changes and Recovery in Physical Function and Fitness After Severe Acute Respiratory Syndrome–Related Coronavirus Infection: Implications for COVID-19 Rehabilitation, Physical Therapy and Rehabilitation Journal

The social threats of COVID-19 for people with chronic pain, The Journal of the International Association for the Study of Pain

Is urinary incontinence associated with sedentary behaviour in older women? Analysis of data from the National Health and Nutrition Examination Survey, PLOS ONE

 

For more information, visit the Ageing Well research group website.

Musculoskeletal Health

For more information, visit the Musculoskeletal Health research group website.

Safeguarding Health through Infection Prevention

Psychomotor learning theory informing the design and evaluation of an interactive augmented reality hand hygiene training app for healthcare workers, Education and Information Technologies

Epidemiology of healthcare-associated infection reported from a hospital-wide incidence study: considerations for infection prevention and control planning, Journal of Hospital Infection

Impact of healthcare-associated infection on length of stay, Journal of Hospital Infection

Personalized infection prevention and control: identifying patients at risk of healthcare-associated infection, Journal of Hospital Infection

Bed-days and costs associated with the inpatient burden of healthcare-associated infection in the UK, Journal of Hospital Infection

Evaluating the post-discharge cost of healthcare-associated infection in NHS Scotland, Journal of Hospital Infection

Factors associated with independent nurse prescribers’ antibiotic prescribing practice: A mixed methods study using the Reasoned Action Approach, Journal of Hospital Infection

Mechanisms affecting the implementation of a national antimicrobial stewardship programme; multi-professional perspectives explained using normalisation process theoryAntimicrobial Resistance & Infection Control Journal

Scoping review of approaches for improving antimicrobial stewardship in livestock farmers and veterinarians, Preventive Veterinary Medicine

The economic benefits of surgical site infection prevention in adults: a systematic review, Journal of Hospital Infection

 

For more information, visit the Safeguarding Health through Infection Prevention research group website.

Sexual Health and Blood Borne Viruses

National population prevalence of antibodies to SARS-CoV-2 among pregnant women in Scotland during the second wave of the COVID-19 pandemic: a prospective national sero-survey, Public Health

Evaluation of the scale-up of HIV testing among people who inject drugs in Scotland in the context of an ongoing HIV outbreak, International Journal of Drug Policy

The uptake of foil from needle and syringe provision services and its role in smoking or snorting heroin among people who inject drugs in Scotland, International Journal of Drug Policy

EPIToPe Recommendations

LUSTRUM: Improving partner notification with Accelerated Partner Therapy

ECDC releases operational guidance on HIV pre-exposure prophylaxis in the EU/EEA and the UK

Population-level effectiveness of a national HIV pre-exposure prophylaxis programme in men who have sex with men, AIDS online journal

Enhanced surveillance of COVID-19 in Scotland: population-based seroprevalence surveillance for SARS-COV-2 during the first wave of the eipdemic, Journal of Public Health

Rapid Epidemiological Analysis of Comorbidities and Treatments as risk factors for COVID-19 in Scotland (REACT-SCOT): A population-based case-control study, PLOS Medicine

Risk of hospital admission with coronavirus disease 2019 in healthcare workers and their households: nationwide linkage cohort study, British Medical Journal

Risk perception, safer sex practices and PrEP enthusiasm: barriers and facilitators to oral HIV preexposure prophylaxis in Black African and Black Caribbean women in the UK, Health Services Research

Genome-Wide Association Study for Alcohol-Related Cirrhosis Identifies Risk Loci in MARC1 and HNRNPUL1, Gastroenterology

 

For more information, visit the Sexual Health and Blood Borne Viruses research group website.

Vision Research

For more information, visit the Vision Research group website.