• ELECTRIC trial (funded by NIHR) which evaluates a simple, non-invasive low cost option aimed at actively treating UI and reducing its impact on residents and care providers by comparing the effectiveness of transcutaneous posterior tibial nerve stimulation (TPTNS) with sham stimulation in 500 CH residents with UI.
  • OPAL trial (funded by NIHR HTA) which investigates the effectiveness of basic pelvic floor muscle exercises versus biofeedback-mediated intensive pelvic floor muscle training for female stress or mixed urinary incontinence. CI Prof Suzanne Hagen.
  • Reasonable adjustments (Baily Thomas Charitable Trust) to provide equitable assessment, screening and treatment of osteoporosis for people with learning disabilities: A feasibility study .  CI Dr Janet Finlayson
  • PREPAID feasibility trial (funded by CSO; £244,085) which aims to determine the feasibility of electrical stimulation used in a patient centred education programme to improve walking distances in patients with intermittent claudication. CI Dr Chris Seenan.
  • PROLONG20+  In 1993-94 ~8,000 women living in Aberdeen, Birmingham and Dunedin (New Zealand) took part in the ProLong study, three months after giving birth. They completed a short incontinence questionnaire at that time which revealed that 33% had UI and 8% had FI. Further questionnaires were completed at 6 years when 45%/10% of the women had UI/FI, and at 12 years when 53%/13% had UI/FI. Prolapse was measured at 12 years and found in 24% of the women. The current study will contact the UK-based ProLong study participants again. Many of the women will be now be around the age of the menopause when pelvic floor dysfunction is thought to be even more common. The women will be asked to take part in a postal questionnaire. An invitation will also be extended for the women to attend a pelvic floor examination. Questionnaire and pelvic floor examination results will be analysed together with NHS medical records. This information will be combined with data from the women in the New Zealand arm of ProLong gathered in 2014 to report how common PFD is and how it relates to childbirth and other risk factors, particularly the menopause. The proposed research constitutes the longest ever prospective follow-up of post-natal PFD worldwide. Findings will help inform estimates of future need for treatment and research, and ultimately improve women’s health during and after pregnancy.
  • TOPSY The TOPSY study aims to assess if self-management of prolapse using a vaginal pessary is more effective at improving women's quality of life than standard follow up care. Women with any severity or kind of prolapse will be invited to take part in the study as long as they have successfully used a pessary for at least 2 weeks. Eligible woman who provide written consent will be assigned randomly to either a self-management or standard care group. Women in the standard care group will be seen every 6 months in a hospital or community clinic for pessary removal and reinsertion. Woman in the self-management group will have a 30 minute appointment with a specialist nurse or physiotherapist to ensure they know how to change and clean their pessary and to allow them time to practice. They will still be fully supported by the clinical team should they require assistance. All women will be followed up for 18 months and we will compare quality of life and other outcomes in the two group.
  • START UP Parkinson’s disease is characterised predominantly by the motor complaints of bradykinesia, rigidity, rest tremor and gait disturbances. However non-motor symptoms are a common accompaniment and lower urinary tract symptoms are reported in 38-71% of people with people with Parkinson’s (PwP) and are an important cause for morbidity and have an immense impact on early institutionalisation and health-related costs. The STARTUP trial will:

    1. Conduct a randomised controlled trial targeting PwP who have self-reported problematic LUT symptoms, investigating the effectiveness of transcutaneous tibial nerve stimulation (TTNS) to sham TTNS.

    2. Implement a standardised training approach and package (already developed) for the correct application of TTNS.

    3. Conduct cost-effectiveness analysis to explore the potential for TTNS to be cost effective in PwP.

    4. Assess fidelity to the TTNS intervention and any research participation effects in the intervention and placebo stimulation groups.

  • SUCCESS The aim of the SUCCESS (Strategies used for Constipation in Children – Evidence Synthesis involving Stakeholders) study is to determine the most effective interventions, and combinations and sequences of interventions, for chronic functional constipation in children, and how they can best be implemented.

    Working in partnership with key stakeholders to ensure relevance and impact, our three-component project will use a pragmatic mixed-method design to:

    1. Conduct a scoping review to comprehensively summarise evidence in this field.

    2. Complete a systematic review (SR) of studies to establish evidence of effectiveness.

    3. Complete a mixed method evidence synthesis to determine factors affecting intervention implementation.

    We will integrate findings from the three components within an interactive digital evidence map to summarise evidence and highlight research gaps in order to facilitate knowledge translation.

    Informed by a dissemination strategy co-produced with key stakeholders, our project will establish evidence of effectiveness of interventions, and combinations and sequences of interventions, for childhood chronic functional constipation, and knowledge of optimal implementation for effective interventions. Addressing our project objectives will uncover optimal interventions and effective implementation planning, which will lead to beneficial outcomes for children, parents/carers and healthcare professionals and ultimately to long term impact.

    Study News:

    The study is due to start on 01.01.2020 and will last for 17 months.

    Resources:

    Team Members:

    Stakeholders:

    Prof     Doreen            McClurg (Principal Investigator)  Glasgow Caledonian University

    Prof     Suzanne          Hagen                                      Glasgow Caledonian University

    Prof     Helen              Mason                                      Glasgow Caledonian University

    Dr        Pauline           Campbell                                  Glasgow Caledonian University

    Dr        Alex               Pollock                                      Glasgow Caledonian University

    Mrs      Lorna              Booth                                       Glasgow Caledonian University

    Ms       Claire              Torrens                                     Glasgow Caledonian University

    Mr       Andrew            Elders                                      Glasgow Caledonian University

    Ms       Juliette            Randall                                    ERIC Children’s Bladder & Bowel

    Mrs      Clare               Millington                                 Patient Public Involvement Rep

    Ms       Deb                 Smith                                      Patient Public Involvement Rep

    Dr       Karen               Jankulak                                  Patient Public Involvement Rep

    Ms       Margaret          Ogden                                     Patient Public Involvement Rep

    Mr       Jonathan          Sutcliffe                                   Leeds General Infirmary

    Collaborators:

    Ms       June                Rogers                                    Bladder and Bowel UK

    Ms       Davina             Richardson                             Association for Continence Advice

    Key Contacts:

    Prof Doreen McClurg (PI) or Lorna Booth

    Nursing, Midwifery and Allied Health Professions Research Unit

    Level 6 Govan Mbeki Building

    Glasgow Caledonian University

    Cowcaddens Road, Glasgow, G4 0BA

    Tel: 0044 141 331 8105

    E-mail: SUCCESS@gcu.ac.uk

    The SUCCESS study is funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme (project: 128470). The study is sponsored by Glasgow Caledonian University.

 

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