Professor Michael Doughty

Professor (Ocular Pharmacology and Physiology)

ROOM: A026
T: +44 141 331 3393
F: +44 (0)141 331 3387
E: m.doughty@gcal.ac.uk

Qualifications

• B.Sc. Biochemistry (upper second class division).  University of London, Bedford College. 1974
• M.Sc. Molecular Enzymology University of Warwick (1975)
• Ph.D. Chemistry & Molecular Sciences (1979)

Graduate Student supervision

Regular involvement in student supervision in research at both undergraduate (honours) and postgraduate level. Students graduated to date:

• 3 MSc (research)
• 1 MPhil
• 7 PhD
• co-supervision of 2 PhD students, 1 MPhil student and 4 MSc (research) students

Teaching

• Ocular anatomy and physiology, general and ocular pharmacology (including diagnostic and therapeutic agents), diseases of the eye–diagnosis and management. Final year honours project supervision.

Publications

Campbell, H., Doughty, M.J., Heron, G., & Ackerley, R.G. (2001). Influence of chronic alcohol abuse and ensuing forced abstinence on static subjective accommodation function in humans. Ophthalmic Physiol Opt, 21 (3), 197-205.

Doughty, M.J. (2001). Consideration of three types of spontaneous eyeblink activity in normal humans: during reading and video display terminal use, in primary gaze, and while in conversation. Optom Vis Sci, 78 (10), 712-725.

Doughty, M.J. (2001). Changes in hydration, protein and proteoglycan composition of the collagen-keratocyte matrix of the bovine corneal stroma ex vivo in a bicarbonate-mixed salts solution, compared to other solutions. Biochim Biophys Acta, 1525 (1-2), 97-107.

Doughty, M.J., Laiquzzaman, M., & Button, N.F. (2001). Video-assessment of tear meniscus height in elderly Caucasians and its relationship to the exposed ocular surface. Curr Eye Res, 22 (6), 420-426.

Doughty, M.J. (2002). Surface features and morphology of bulbar conjunctival cells of bovine eyes obtained from a slaughterhouse: a scanning electron microscope and impression cytology study. Curr Eye Res, 24 (5), 341-353.

Doughty, M.J. (2002). Further assessment of gender- and blink pattern-related differences in the spontaneous eyeblink activity in primary gaze in young adult humans. Optom Vis Sci, 79 (7), 439-447.

Doughty, M.J., Blades, K.A., & Ibrahim, N. (2002). Assessment of the number of eye symptoms and the impact of some confounding variables for office staff in non-air-conditioned buildings. Ophthalmic Physiol Opt, 22 (2), 143-155.

Doughty, M.J., Laiquzzaman, M., Muller, A., Oblak, E., & Button, N.F. (2002). Central corneal thickness in European (white) individuals, especially children and the elderly, and assessment of its possible importance in clinical measures of intra-ocular pressure. Ophthalmic Physiol Opt, 22 (6), 491-504.

Doughty, M.J., Laiquzzaman, M., Oblak, E., & Button, N. (2002). The tear (lacrimal) meniscus height in human eyes: a useful clinical measure or an unusable variable sign? Cont Lens Anterior Eye, 25 (2), 57-65.

Doughty, M.J., Oriowo, O.M., & Cullen, A.P. (2002). Morphometry of the corneal endothelium in glassblowers compared to non-glassblowers. J Photochem Photobiol B, 67 (2), 130-138.

Muller, A., & Doughty, M.J. (2002). Assessments of corneal endothelial cell density in growing children and its relationship to horizontal corneal diameter. Optom Vis Sci, 79 (12), 762-770.

Muller, A., Doughty, M.J., & Watson, L. (2002). A retrospective pilot study to assess the impact of strabismus surgery on the corneal endothelium in children. Ophthalmic Physiol Opt, 22 (1), 38-45.

Oblak, E., & Doughty, M.J. (2002). Chronic exposure to the ultraviolet radiation levels from arc welding does not result in obvious damage to the human corneal endothelium. Photochem Photobiol Sci, 1 (11), 857-864.

Oblak, E., Doughty, M.J., & Oblak, L. (2002). A semi-automated assessment of cell size and shape in monolayers, with optional adjustment for the cell-cell border width-application to human corneal endothelium. Tissue Cell, 34 (4), 283-295.

Aakre, B.M., Doughty, M.J., Dalane, O.V., Berg, A., Aamodt, O., & Gangstad, H. (2003). Assessment of reproducibility of measures of intraocular pressure and central corneal thickness in young white adults over a 16-h time period. Ophthalmic and Physiological Optics, 23 (3), 271-283.

Donald, C., Hamilton, L., & Doughty, M.J. (2003). A quantitative assessment of the location and width of Marx's line along the marginal zone of the human eyelid. Optom Vis Sci, 80 (8), 564-572.

Doughty, M.J. (2003). A physiological perspective on the swelling properties of the mammalian corneal stroma. Cont Lens Anterior Eye, 26 (3), 117-129.

Doughty, M.J. (2003). Impact of brief exposure to balanced salts solution or cetylpyridinium chloride on the surface appearance of the rabbit corneal epithelium--a scanning electron microscopy study. Curr Eye Res, 26 (6), 335-346.

Hughes, C., Hamilton, L., & Doughty, M.J. (2003). A quantitative assessment of the location and width of Marx's line along the marginal zone of the human eyelid. Optometry and Vision Science, 80 (8), 564-572.

Thuret, G., Manissolle, C., Acquart, S., Le Petit, J.C., Maugery, J., Campos-Guyotat, L., Doughty, M.J., & Gain, P. (2003). Is manual counting of corneal endothelial cell density in eye banks still acceptable? The French experience. British Journal of Ophthalmology, 87 (12), 1481-1486.

Aakre, B.M., Ystenaes, A.E., Doughty, M.J., Austrheim, O., Westerfjell, B., & Lie, M.T. (2004). A 6-month follow-up of successful refits from daily disposable soft contact lenses to continuous wear of high-Dk silicone-hydrogel lenses. Ophthalmic and Physiological Optics, 24 (2), 130-141.

Doughty, M.J. (2004). Impact of hypotonic solutions on the stromal swelling, lactate dehydrogenase and aldehyde dehydrogenase activity of the keratocytes of the bovine cornea. Cell Biol Int, 28 (8-9), 593-607.

Doughty, M.J. (2004). Influence of initial fixation protocol on the appearance of primary cilia on the rabbit corneal endothelial cell apical surface as assessed by scanning electron microscopy. Cell Biol Int, 28 (2), 131-137.

Doughty, M.J. (2004). Further assessment of the size, shape and surface features of superficial cells of the bovine corneal epithelium, using scanning electron microscopy. Curr Eye Res, 28 (3), 203-214.

Doughty, M.J., & Bergmanson, J.P. (2004). Heterogeneity in the ultrastructure of the mucous (goblet) cells of the rabbit palpebral conjunctiva. Clin Exp Optom, 87 (6), 377-385.

Doughty, M.J., & Bergmanson, J.P. (2004). Collagen fibril characteristics at the corneo-scleral boundary and rabbit corneal stromal swelling. Clin Exp Optom, 87 (2), 81-92.

Doughty, M.J., Naase, T., Donald, C., Hamilton, L., & Button, N.F. (2004). Visualisation of "Marx's line" along the marginal eyelid conjunctiva of human subjects with lissamine green dye. Ophthalmic Physiol Opt, 24 (1), 1-7.

Doughty, M.J., Aakre, B.M., Ystenaes, A.E., & Svarverud, E. (2005). Short-term adaptation of the human corneal endothelium to continuous wear of silicone hydrogel (lotrafilcon A) contact lenses after daily hydrogel lens wear. Optom Vis Sci, 82 (6), 473-480.

Doughty, M.J., & Bergmanson, J.P. (2005). Resolution and reproducibility of measures of the diameter of small collagen fibrils by transmission electron microscopy--application to the rabbit corneal stroma. Micron, 36 (4), 331-343.

Doughty, M.J., Jalota, V., Bennett, E., Naase, T., & Oblak, E. (2005). Use of a high molecular weight fluorescein (fluorexon) ophthalmic strip in assessments of tear film break-up time in contact lens wearers and non-contact lens wearers. Ophthalmic Physiol Opt, 25 (2), 119-127.

Doughty, M.J., & Oblak, E. (2005). A clinical assessment of the anterior eye in arc welders. Clin Exp Optom, 88 (6), 387-395.

Naase, T., Doughty, M.J., & Button, N.F. (2005). An assessment of the pattern of spontaneous eyeblink activity under the influence of topical ocular anaesthesia. Graefes Arch Clin Exp Ophthalmol, 243 (4), 306-312.

Doughty, M.J. (2006). Quantitative analysis of ring-shaped (crater-like) features at the tear film-epithelial interface of the rabbit cornea as assessed by scanning electron microscopy. Curr Eye Res, 31 (12), 999-1010.

Doughty, M.J. (2006). Subjective vs. objective analysis of the corneal endothelial cells in the rabbit cornea by scanning electron microscopy - a comparison of two different methods of corneal fixation. Vet Ophthalmol, 9 (2), 127-135.

Doughty, M.J., & Dutton, G.N. (2006). Fusidic acid viscous eyedrops--an evaluation of pharmacodynamics, pharmacokinetics and clinical use for UK optometrists. Ophthalmic Physiol Opt, 26 (4), 343-361.

Doughty, M.J., & Naase, T. (2006). Further analysis of the human spontaneous eye blink rate by a cluster analysis-based approach to categorize individuals with 'normal' versus 'frequent' eye blink activity. Eye Contact Lens, 32 (6), 294-299.

Doughty, M.J., & Aakre, B.M. (2007). Central versus paracentral endothelial cell density values in relation to duration of soft contact lens wear. Eye Contact Lens, 33 (4), 180-184.

Doughty, M.J., & Jonuscheit, S. (2007). Effect of central corneal thickness on Goldmann applanation tonometry measures-a different result with different pachymeters. Graefes Arch Clin Exp Ophthalmol,

Doughty, M.J., & Jonuscheit, S. (2007). An assessment of regional differences in corneal thickness in normal human eyes, using the Orbscan II or ultrasound pachymetry. Optometry, 78 (4), 181-190.

Doughty, M.J., Lee, C.A., Ritchie, S., & Naase, T. (2007). An assessment of the discomfort associated with the use of rose bengal 1% eyedrops on the normal human eye: a comparison with saline 0.9% and a topical ocular anaesthetic. Ophthalmic Physiol Opt, 27 (2), 159-167.

Doughty, M.J., McIntosh, M., McFadden, S., & Button, N.F. (2007). Impression cytology of a case of conjunctival metaplasia associated with oral carbamazepine use? Cont Lens Anterior Eye, 30: 254 - 257.

Doughty, M.J., Whyte, J., & Li, W. (2007). The phenol red thread test for lacrimal volume--does it matter if the eyes are open or closed? Ophthalmic Physiol Opt, 27 (5), 482-489.

Jonuscheit, S., & Doughty, M.J. (2007). Regional repeatability measures of corneal thickness: Orbscan II and ultrasound. Optom Vis Sci, 84 (1), 52-58.

Jonuscheit, S., Doughty, M.J., & Button, N.F. (2007). On the use of Orbscan II to assess the peripheral corneal thickness in humans: a comparison with ultrasound pachometry measures. Ophthalmic Physiol Opt, 27 (2), 179-189.

Doughty, M.J. (2008). Could the coefficient of variation (COV) of the corneal endothelium be overestimated when a centre-dot method is used? Clin Exp Optom, 91 (1), 103-110.

Doughty MJ, Gillis N, MacGill J, Montgomery DM (2008) Goldmann tonometry and pachymetry measures in patients with and without topical medical treatment at a glaucoma clinic. Ophthalmic Physiological Optics 28, 558-567

Mathew JH, Bergmanson JPG, Doughty MJ (2008) Fine structure of the interface beween the anterior limiting lamina and the anterior stromal fibrils of the human cornea. Investigative Ophthalmology Visual Science 49, 3914-3918

Doughty MJ, Aakre BM (2008) Further analysis of assessments of the coefficient of variation of corneal endothelial cell areas from specular microscope images. Clinical Experimental Optometry 91, 438-446

Doughty MJ, Naase T (2008) Nucleus and cell size changes in human bulbar conjunctival cells after soft contact lens wear, as assessed by impression cytyology. Contact Lens Anterior Eye 31. 131-140

Walsh JE, Bergmanson JPG, Koehler LV, Doughty MJ, Fleming D, Harmey JH (2008) Optimising the methodology for measuring corneal spectral transmittance. Physiological Measurement 29, 375-388

Doughty MJ (2008) Normal features of superficial non-desquamating cells of the rabbit corneal epithelium assessed by scanning electron microscopy. Veterinary Ophthalmology 11, 81-90

Doughty MJ, Bergmanson JPG (2008) Use of a stroma perfusion technique and transmission electron microscopy to assess ultrastructural changes associated with exposure to slightly acid pH 5.75 solutions. Current Eye Research 33, 45-57

Doughty MJ, Oblak E (2008) A comparison of two methods for estimating polymegethism in cell areas of the human corneal endothelium. Ophthalmic Physiological Optics 28, 47-56. [191]

Doughty MJ, Glavin S (2009) Efficacy of different dry eye treatments with artificial tears or ocular lubricants – a systematic review. Ophthalmic Physiological Optics 29: 573-583

Jonuscheit S, Doughty MJ (2009) Evidence for a relative thinning of the peripheral cornea with age in white European subjects. Investigative Ophthalmology & Visual Science 50: 4121-4128.

Doughty MJ (2009) BOOK CHAPTER. Basic pharmacology relevant to the action of drugs on the eye. In - Optometry: Science, Techniques and Clinical Management (Rosenfield M, Logan N, eds). Butterworth Heinemann / Elsevier, Edinburgh. Chapter 6, pp. 77-88

Doughty MJ, Naase T, Button NF (2009) Frequent spontaneous eyeblink activity associated with reduced conjunctival surface (trigeminal nerve) tactile sensitivity. Von Graefes Archives Clinical Experimental Ophthalmology 247, 939-946

Jonuscheit S, Doughty MJ (2009) Repeatability of central corneal thickness measures by Orbscan for right and left eyes. Eye Contact Lens 35, 20-25

Doughty MJ (2010) Assessment of agreement for assignment of a normal grade to human conjunctival impression cytology samples. Cytopathology – accepted for publication

Doughty MJ (2010) pH-dependent spectral properties of sodium fluorescein ophthalmic solutions revisited. Ophthalmic Physiological Optics – accepted for publication

Jonuscheit S, Doughty MJ (2010) Discrepancy between central and mid-peripheral corneal thickness measures obtained with scanning slit pachymetry and non-contact specular microscopy. Journal Cataract & Refractive Surgery – in press