Professor of Vascular Cell Biology
Departmental Research Coordinator
Deputy Radiation Protection Officer
T: +44 (0)141 331 3722
- The role of intracellular lipid transporters in health and disease:
- Atherosclerosis, Alzheimer’s disease and Type 2 diabetes mellitus
- Member of the Diabetes Research Group
- Module lead: Cell Signalling and Trafficking
- Honours project coordinator
Selected recent Publications:
- Ianitti, T., Graham, A. and Dolan, S. (2012) Increased central and peripheral inflammation and inflammatory hyperalgesia in Zucker rat model of leptin receptor deficiency and genetic obesity. In press: doi.10.1113/expphysiol.2011.064220.
- Elbadawy, H.M., Borthwick, F., Wright, C., Martin, P.E. and Graham, A. (2011) Cytosolic StAR-related lipid transfer domain 4 (STARD4) protein influences keratinocyte lipid phenotype and differentiation status. British Journal of Dermatology 164:628-632.
- Borthwick, F., Allen, A.M., Taylor, J.M. and Graham, A. (2010) Over-expression of STARD3 in human monocyte-macrophages induces an anti-atherogenic lipid phenotype. Clinical Science 119: 265-272
- Taylor, J.M.W., Borthwick, F., Bartholomew, C. and Graham, A. (2010) Over-expression of steroidogenic acute regulatory protein (StAR) increases macrophage cholesterol efflux to apolipoprotein AI. Cardiovascular Res. 86: 526-534
- Graham, A. (2009) Curcumin adds spice to the debate: lipid metabolism in liver disease. Br. J. Pharmacol. 157: 1354-57.
- Borthwick, F., Taylor, J.M., Bartholomew, C. and Graham, A. (2009) Differential regulation of the STARD1 subfamily of START lipid trafficking proteins in human (THP-1) macrophages. FEBS Letters 583: 1147-53.
- Robertson, S.A., Rae, C.J. and Graham, A. (2009) Induction of angiogenesis by murine resistin: putative role of PI3-kinase and NO dependent pathways. Regulatory Peptides 152:41-47
- Robertson, S.A., Rae, C.J. and Graham, A. (2009) Resistin: TWEAKing angiogenesis. Atherosclerosis 203: 34-37.
- Rae, C.J. and Graham, A. (2008) Fatty acid synthase inhibitor, C75, blocks resistin-induced increases in lipid accumulation by human macrophages. Diabetes, Obesity and Metabolism 10: 1271-1274
- Riba, R., Hughes, C.E., Graham, A., Watson, S.P. and Naseem, K.M. (2008) Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor gamma chain complex. J. Thromb. Haemostasis 6:1012-1020
- Heart Research UK, Translational project grant ‘An exploration of the anti-atherogenic potential of compounds targeting mitochondrial cholesterol transporter protein (TSPO) and the cholesterol efflux pathway’ £90,000 (2012-2014) with Prof Michael Kassiou (University of Sydney), Dr Xinhua Shu (GCU) and Dr Patricia Martin (GCU).
- Diabetes UK, small grant on ‘Diabetic dyslipidaemia: the role of intracellular lipid transport proteins’ £15,000 (2011-13) with Dr Sharron Dolan (GCU).
- Alzheimer’s Research UK, pilot project grant ‘START intracellular cholesterol transport and beta amyloid production’ £29,996 (2011-2012).
Current research team:
- Dr Janice Taylor
- Ms Anne Marie Allen (1.0 postdoctoral researcher)
- Mr Ugo Soffientini (PhD)
- Miss Joana Borges Pinto (PhD)
- Professor Michael Kassiou, University of Sydney
- Dr Faye Borthwick undertook her PhD in my group from 2005-2008. She currently holds a Canadian (CIBE) Fellowship, and is working with Dr Spencer Proctor, in the Metabolic and Cardiovascular Diseases Laboratory, Molecular and Cell Biology of Lipids Group, Alberta Diabetes and Mazankowski Heart Institutes, Edmonton, Alberta.
- Dr Hossein Elbadaway (2007-2010) worked on a PhD project funded by the British Skin Foundation, and is currently working as a research scientist at Fondazione Banca degli Occhi del Veneto, Zelarino, Venezia
- Fellow of the Higher Education Academy
- External PhD Examiner for the Universities of Newcastle-upon-Tyne, Glasgow, Nottingham Trent, Warwick, Sydney