Reader in Clinical Virology
T: +44 (0)141 331 8534
Dr Scobie is a Reader in the Department of Life Sciences who is involved in teaching on the Biomedical Science and Microbiology programmes. In addition, Dr Scobie leads a research group interested in viral zoonoses in the context of novel technologies such as xenotransplantation, and the contribution and/or reactivation of viruses in chronic disease conditions.
- PhD student – Zoe O’Hara. Title of project: Hepatitis E virus in the environment and commercial food sources. University funded studentship (October 2012 – 2015)
Funded projects to date
- European Union FP7-HEALTH-2011-single-stage number 281493. January 2012 – December 2014. TRIAD: Tolerance Restoration In Autoimmune Diseases by selective manipulation of the CD28 costimulatory pathway.
- Chief Scientist Office Scotland, ETM/32. October 2010 - September 2012. Epidemiology and Identification of Potential Transmission routes for autochthonous Hepatitis E virus (HEV) in Scotland and the clinical relevance of HEV in chronic liver disease. £231, 631.
- European Union Framework Programme 6, LSHB-CT-2006-037377. November 2006 - November 2011. Xenome: Superengineering of the porcine genome for xenotransplantation studies in primates: a step towards clinical application. 427,226 euros.
- Retroviraemia in pigs:potential role in disease. National Pork Board/Iowa State University. April 2008 – December 2009. $4951
- Government funding from the Department of Health. May 2004 to December 2007. Retroviral vectors for gene therapy: assessing the risks of oncogenesis. £450,276
- Medical Research Council Scotland. August 2004 to August 2006: Control of human tropic Replication Competent Porcine Endogenous Retroviruses (PERV) in cells and organs for xenotransplantation. £98,082
- Wellcome Trust Vacastion Scholarship 2006. Development of donor animals more suitable for use in organ/tissue xenotransplantation. £1,190
- Mapping and characterisation of porcine endogenous retrovirus from miniature swine. Industrial funding by Immerge BioTherapeutics Inc, 300 Technology Square, Cambridge, Boston, MA 02139, USA. January 2002 to April 2004. £213,586
- Analysis of full length integrated porcine endogenous retroviruses and their infectious potential in xenotranplantation. Scottish Hospitals Endowments Research Trust (SHERT). May 2002 to February 2004. £60,094
- Analysis of LTR sequences from human tropic and non-human tropic porcine endogenous retroviruses. The Wellcome Trust. Vacation Scholarship July 2003 - August 2003. £950
Bibliography in peer reviewed journals (2007-2012)
- Claire Crossan, Paul J Baker, John Craft, Yasu Takeuchi, Harry R Dalton and Linda Scobie. Identification of Hepatitis E virus Genotype-3 in shellfish in the United Kingdom. 2012, 18 (12) Emerging Infectious Diseases.
- Martien Groenen, Alan Archibald, Hirohide Uenishi, Christopher Tuggle, Yasu Takeuchi et al. Pig genomes provide insight into porcine demography and evolution. 2012, Nov 15;491(7424):393-8 Nature.
- Hepatitis E: source and route of infection, clinical manifestations and new developments. Scobie L, Dalton HR.J Viral Hepat. 2013 Jan;20(1):1-11. doi: 10.1111/jvh.12024
- Alex Harrison A, Linda Scobie, Claire Crossan, Rob Parry, Paul Johnston, Jon Stratton, Steve Dickinson, Vic Ellis, Jeremy G Hunter, Oliver R Prescott, Richie Madden,Nan X Lin, William E Henley, Richard P Bendall, Harry R Dalton. Hepatitis E seroprevalence in recipients of renal transplants or haemodialysis in Southwest England: a case-control study. 2012. Journal of Medical Virology Nov 20.
- Fishman, Scobie and Takeuchi, Xenotransplantation-associated Infectious Risk: a WHO consultation. Xenotransplantation. 2012 Mar-Apr;19(2):72-81. doi: 10.1111/j.1399-3089.2012.00693.x.
- Xenotransplantation of Galactosyl-transferase knock-out, CD55, CD59 CD39 and fucosyl transeerase transgenic pig kidneys into baboons. Le Bas-Bernardet, Tillou X, Poirier N, Dilek N, Chatelais M, Julie Devallière, Charreau B, Minault D, Hervouet J, Renaudin K, Crossan C, Scobie L, Cowan PJ, d’Apice AJF, Galli C, Cozzi E, Soulillou JP, Vanhove B and Blancho G., Transplant Proc. 2011 Nov;43(9):3426-30
- Detection of porcine endogenous retrovirus (PERV) viremia in diseased versus healthy U.S. pigs by quantitative real-time RT-PCR. Narinder P, RR. Baker, S Schalk, L Scobie, A W. Tucker, T Opriessnig; Transbound Emerg Dis. Transbound Emerg Dis. 2011 Aug;58(4):344-51. doi: 10.1111/j.1865-1682.2011.01210.x. Epub 2011 Mar 13.
- Microbial Safety in Xenotransplantation. Mueller NJ, Takeuchi Y, Mattiuzzo G, Scobie L. Curr Opin Organ Transplant. 2011 Apr;16(2):201-6.
- Zhou P, Hatziieremia S, Elliott MA, Scobie L, Crossan C, Michie AM, Holyoake TL, Halbert GW, Jørgensen HG. Uptake of synthetic Low Density Lipoprotein by leukemic stem cells - a potential stem cell targeted drug delivery strategy. J Control Release. 2010 Sep 22 Epub ahead of press.
- Mattiuzzo G, Takeuchi Y and Scobie L. Xenotransplantation: Methods and Protocols. (2010) Methods in Molecular Biology, Humana Press; in press.
- Scobie L. Porcine pathogens and xenotransplantation: PERV and beyond! Xenotransplantation (2010): 17: 94–120
- Bakri M, Sutherland A, Brown D, Crossan C, Vesely P and Scobie L. Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts. (2009) Xenotransplantation Nov;16(6):472-6.
- Scobie L and Takeuchi Y. PERV and other viruses in xenotransplantation. (2009) Curr Opin Organ Transplant 17 (16): 1031-8.
- Scobie L, Hector RD, Grant L, Bell M, Nielsen AA, Meikle S, Philbey A, Thrasher AJ, Cameron ER, Blyth K, Neil JC. A Novel Model of SCID-X1 Reconstitution Reveals Predisposition to Retrovirus-induced Lymphoma but No Evidence of gamma C Gene. Oncogenicity. (2009) Molecular Therapy 14 (2): 175-9.
- Garkavenko O, Wynyard S, Nathu D, Muzina M, Muzina Z, Scobie L, et al. Porcine endogenous retrovirus transmission characteristics from a designated pathogen-free herd. (2008) Transplant Proc. Mar;40(2):590-3
- Garkavenko O, Wynyard S, Nathu D, Simond D, Muzina M, Muzina Z, Scobie L, Hector RD, Croxson MC, Tan P, Elliott BR. Porcine endogenous retrovirus (PERV) and its transmission characteristics: a study of the New Zealand designated pathogen-free herd. (2008) Cell Transplant;17(12):1381-8
- Mattiuzzo G, Scobie L, Takeuchi Y. Strategies to enhance the safety profile of xenotransplantation: minimizing the risk of viral zoonoses. (2008) Curr Opin Organ Transplant. Apr;13(2):184-8.
- Monica Stewart, Nancy Mackay, Linda Hanlon, Karen Blyth, Linda Scobie, Ewan Cameron and James C. Neil. (2007) Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas. Cancer Research, 67 (11), 5126-33.
- Ralph D Hector, Sharon Meikle, Louise Grant, Robert Wilkinson, Jay Fishman and Linda Scobie. (2007) Pre-screening of miniature swine may reduce the risk of transmitting human tropic replication competent recombinant PERV. Xenotransplantation.14 (3),222-6.
- Thrasher A, Gaspar B., Baum C, Modlich U., Sambach A., Candotti F., Sorrentino B., Scobie L., et al. (2006) Lack of Transgene leukaemogenicity. Nature: 443(7109)
- Mattiuzzo G, Takeuchi Y and Scobie L. Potential Zoonotic Infection of Porcine Endogenous Retrovirus in Xenotransplantation Methods in Molecular Biology, 2012, Volume 885, 263-279.
- L Scobie and O Garkavenko – Chapter 5. Porcine endogenous retroviruses (PERVs) in xenotransplantation. The Minipig in Biomedical Research. Editor: P A McAnulty. Publisher Taylor and Francis 2011.
- AW Tucker and L Scobie – Chapter 40. Retroviruses. 10th Edition of Diseases of Swine. Editor: J Zimmerman. Publisher Wiley Blackwell 2012. This text is used in Veterinary Schools in the UK as a teaching text.